#Note/Permanent #Neuroscience #Health/Sleep #Adenosine ## Overview of Adenosine [Adenosine](https://en.wikipedia.org/wiki/Adenosine) is a neurotransmitter that plays a crucial role in regulating sleep. It is a byproduct of neuronal activity in the brain and accumulates during wakeful periods. ## Function in Sleep Regulation - **Accumulation During Wakefulness**: Adenosine levels gradually increase throughout the day, contributing to the build-up of sleep pressure. - **Promotion of Sleep**: High levels of adenosine in the brain signal the body that it is time to rest, facilitating the onset of sleep. ## Interaction with Caffeine - **Caffeine's Effect**: Caffeine blocks adenosine receptors, particularly the A₁ subtype, reducing sleep pressure and promoting alertness. - **Impact on Sleep Cycle**: While caffeine can temporarily mask the sleep-inducing effects of adenosine, it does not reduce its overall levels in the brain. ## Importance in Sleep Quality - **Sleep and Adenosine Clearance**: Adequate sleep allows for the clearance of adenosine from the brain, resetting the sleep-wake cycle.